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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Zygotic Development And Stem Cell Formation01:10

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Multipotent Stem Cell and Reproduction.

Neda Khanlarkhani1, Maryam Baazm2, Farzaneh Mohammadzadeh1

  • 1Department of Anatomical Sciences, Medical School, Tehran University, Tehran, Iran.

Journal of Stem Cells
|March 16, 2017
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Summary
This summary is machine-generated.

Multipotent stem cells are versatile cells crucial for development and tissue repair. Research explores their therapeutic potential, especially in treating infertility disorders.

Keywords:
FertilityMSC-based therapiesMultipotentPreservationStem cell

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Area of Science:

  • Stem cell biology
  • Regenerative medicine

Background:

  • Stem cells are undifferentiated cells with self-renewal and differentiation capabilities.
  • Stem cells are broadly classified into embryonic and adult types, and by differentiation potential (totipotent, pluripotent, multipotent, unipotent).
  • Multipotent stem cells can differentiate into specific cell lineages.

Purpose of the Study:

  • To highlight the advantages and applications of multipotent stem cells.
  • To discuss their role in development, tissue repair, and protection.
  • To explore their potential in medical treatments and MSC-based therapies, including infertility disorders.

Main Methods:

  • Review of stem cell classification and properties.
  • Analysis of multipotent stem cell functions in biological processes.
  • Examination of current research trends in stem cell therapeutics.

Main Results:

  • Multipotent stem cells are vital for development and tissue regeneration.
  • Their accessibility and adaptability make them promising therapeutic agents.
  • Ongoing research focuses on optimizing Mesenchymal Stem Cell (MSC)-based therapies.

Conclusions:

  • Multipotent stem cells offer significant therapeutic advantages.
  • Further research is needed to fully harness their potential in medicine.
  • Stem cell biology presents new avenues for treating infertility.