Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

12.5K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
12.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extended High-Dose Tofacitinib Induction Improves Clinical Response in Ulcerative Colitis: A Multicenter Cohort Study.

JGH open : an open access journal of gastroenterology and hepatology·2026
Same author

Direct health care costs of managing perianal Crohn's Disease in a population based cohort.

Scandinavian journal of gastroenterology·2021
Same author

<i>Rhodococcus equi</i>: Another great masquerader.

IDCases·2021
Same author

The Fetus with Ganglionic Eminence Abnormality: Head Size and Extracranial Sonographic Findings Predict Genetic Diagnoses and Postnatal Outcomes.

AJNR. American journal of neuroradiology·2021
Same author

Burning Feet, Dilated Heart and Failed Kidneys.

Indian journal of nephrology·2019
Same author

Tetracyclines for Treatment of Tularemia: A Case Series.

Open forum infectious diseases·2018

Related Experiment Video

Updated: Mar 6, 2026

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
08:35

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Published on: May 29, 2021

7.3K

Enabling Chemistry Technologies and Parallel Synthesis-Accelerators of Drug Discovery Programmes.

A Vasudevan1, A R Bogdan1, H F Koolman1

  • 1Discovery Chemistry and Technology, North Chicago, IL, United States.

Progress in Medicinal Chemistry
|March 19, 2017
PubMed
Summary
This summary is machine-generated.

Pharmaceutical companies can boost productivity by investing in new chemistry technologies. These innovations reduce cycle times, lower costs, and improve the success rate for synthesizing novel drug candidates and in parallel synthesis.

Keywords:
AbbVie chemistry technologyDRIFTElectrochemistryFlow chemistryFlow photochemistryHazardous reagents in flowHigh-temperature chemistryHigh-throughput chemistryLOPHTORLibrary design toolParallel synthesisPhoenixSWIFTSynthetic methods

More Related Videos

The Automated Crystallography Pipelines at the EMBL HTX Facility in Grenoble
06:50

The Automated Crystallography Pipelines at the EMBL HTX Facility in Grenoble

Published on: June 5, 2021

4.1K
Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
07:20

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

4.5K

Related Experiment Videos

Last Updated: Mar 6, 2026

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
08:35

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Published on: May 29, 2021

7.3K
The Automated Crystallography Pipelines at the EMBL HTX Facility in Grenoble
06:50

The Automated Crystallography Pipelines at the EMBL HTX Facility in Grenoble

Published on: June 5, 2021

4.1K
Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
07:20

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

4.5K

Area of Science:

  • Medicinal Chemistry
  • Process Chemistry
  • Pharmaceutical Development

Background:

  • The pharmaceutical industry faces challenges in optimizing productivity.
  • Investments in advanced chemistry technologies are crucial for improving efficiency.
  • Key metrics impacted include cycle times, cost of goods, and technical success rates.

Purpose of the Study:

  • To highlight chemistry technologies that enhance pharmaceutical productivity.
  • To showcase applications in novel scaffold synthesis and parallel synthesis.
  • To provide insights from AbbVie's development and implementation experiences.

Main Methods:

  • Review and description of implemented chemistry technologies.
  • Case studies on applications in novel scaffold synthesis.
  • Examples of parallel synthesis strategies utilizing these technologies.

Main Results:

  • Demonstrated impact of specific technologies on reducing cycle times.
  • Evidence of cost reductions in the cost of goods.
  • Improved probability of technical success in drug development projects.
  • Successful application in generating diverse chemical libraries.

Conclusions:

  • Strategic investment in chemistry technologies is vital for pharmaceutical productivity.
  • These technologies enable efficient synthesis of novel molecular architectures.
  • AbbVie's experience underscores the value of technological innovation in drug discovery and development.