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Pigmentation01:19

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Quantification of Hypopigmentation Activity In Vitro
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Depigmentation Therapies for Vitiligo.

Pearl E Grimes1, Rama Nashawati2

  • 1Vitiligo & Pigmentation Institute of Southern California, 5670 Wilshire Boulevard #650, Los Angeles, CA 90036, USA; Division of Dermatology, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.

Dermatologic Clinics
|March 21, 2017
PubMed
Summary
This summary is machine-generated.

For extensive vitiligo unresponsive to repigmentation, depigmentation of remaining skin offers an alternative. Careful patient selection and education are crucial for this treatment approach.

Keywords:
4-MethoxyphenolDepigmentationDisorders of appearanceMBEHMequinolMonobenzyl ether of hydroquinonePigmentary disordersVitiligo

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Area of Science:

  • Dermatology
  • Medical Treatments

Background:

  • Vitiligo management typically aims for repigmentation.
  • Extensive vitiligo unresponsive to therapy presents unique challenges.

Purpose of the Study:

  • To explore depigmentation as a treatment option for specific vitiligo cases.
  • To highlight considerations for depigmentation therapy.

Main Methods:

  • Review of depigmentation therapies for vitiligo.
  • Discussion of topical agents: monobenzyl ether of hydroquinone, 4-methoxyphenol, and 88% phenol.
  • Inclusion of physical modalities: cryotherapy and lasers.

Main Results:

  • Depigmentation is a viable option for select vitiligo patients.
  • Effective topical and physical treatments are available.

Conclusions:

  • Careful screening and patient education are essential for depigmentation therapy.
  • Depigmentation offers an alternative when repigmentation fails in extensive vitiligo.