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Arthritis in patients with psoriasis is associated with an immunoglobulin gene polymorphism
L I Sakkas1, A G Demaine, G S Panayi
1Rheumatology Unit, United Medical School, Guy's Hospital, London, UK.
Arthritis and Rheumatism
|February 1, 1988
Abstract:
Using a DNA probe for the switch region of immunoglobulin heavy chain genes, together with the restriction endonuclease Sst I, we detected a particular polymorphic DNA pattern in 17 of 28 patients (60.7%) with psoriatic arthropathy but in only 5 of 41 patients (12.2%) with psoriasis alone. Our findings suggest that genes in the immunoglobulin region confer susceptibility to the development of arthropathy in patients with psoriasis.