Primary Pulmonary Diffuse Large B Cell Non-Hodgkin's Lymphoma: A Case Report and Literature Review

Area of Science:

• Oncology
• Pulmonology
• Hematology

Background:

• Primary pulmonary diffuse large B cell lymphoma (DLBCL) is an exceptionally rare malignancy, accounting for only 0.5-1% of all primary lung cancers.
• Clinical and radiological presentations are often non-specific, complicating early detection.

Observation:

• A case report details a middle-aged Hispanic woman presenting with chronic cough and a lung mass on chest X-ray.
• The patient was diagnosed with primary pulmonary DLBCL.

Findings:

• The patient received 6 cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) therapy.
• Complete remission was achieved following treatment.

Implications:

• Increased awareness of primary pulmonary DLBCL is crucial for accurate diagnosis, impacting therapeutic strategies and patient prognosis.
• Treatment decisions for primary pulmonary DLBCL should consider tumor biology, disease stage, and patient performance status.