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Increased Body Temperature

Increased Body Temperature

A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...

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The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:

Types of Fever

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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

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Related Experiment Video

Updated: Mar 6, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Febrile infant update.

Kate Dorney¹, Richard G Bachur

¹Division of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.

Current Opinion in Pediatrics

|March 22, 2017

Summary

This summary is machine-generated.

Caring for febrile infants under 90 days is complex. Biomarkers like C-reactive protein (CRP) and procalcitonin aid in identifying serious bacterial infections (SBI), improving infant care.

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Published on: October 29, 2014

Area of Science:

Pediatrics
Infectious Diseases
Neonatology

Background:

Febrile infants under 90 days present a diagnostic challenge.
Management strategies are evolving with new research.
Serious bacterial infections (SBI) require prompt identification.

Purpose of the Study:

To provide an updated review on managing febrile infants younger than 90 days.
To focus on the epidemiology of SBI, biomarker-based management, and novel diagnostics.
To refine diagnostic and management approaches for febrile neonates.

Main Methods:

Review of current literature on febrile infant management.
Analysis of biomarker utility (CRP, procalcitonin) for risk stratification.
Evaluation of novel diagnostic tools such as RNA and protein signatures.

Main Results:

High variability exists in emergency department management of febrile infants.
C-reactive protein (CRP) and procalcitonin are valuable for risk-stratifying infants.
Urine concentration impacts the diagnostic value of pyuria in suspected urinary tract infections (UTI).
Novel diagnostics show promise in identifying infants with serious infections.

Conclusions:

Urinary tract infection (UTI) is the most common SBI in febrile infants.
Procalcitonin and CRP in prediction algorithms help identify low-risk infants.
Accurate diagnosis of invasive bacterial infections in infants remains a challenge.