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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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Febrile infant update

Kate Dorney1, Richard G Bachur

  • 1Division of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.

Current Opinion in Pediatrics
|March 22, 2017
PubMed

Insights

Caring for febrile infants under 90 days is complex. Biomarkers like C-reactive protein (CRP) and procalcitonin aid in identifying serious bacterial infections (SBI), improving infant care.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neonatology

Background:

  • Febrile infants under 90 days present a diagnostic challenge.
  • Management strategies are evolving with new research.
  • Serious bacterial infections (SBI) require prompt identification.

Purpose of the Study:

  • To provide an updated review on managing febrile infants younger than 90 days.
  • To focus on the epidemiology of SBI, biomarker-based management, and novel diagnostics.
  • To refine diagnostic and management approaches for febrile neonates.

Main Methods:

  • Review of current literature on febrile infant management.
  • Analysis of biomarker utility (CRP, procalcitonin) for risk stratification.
  • Evaluation of novel diagnostic tools such as RNA and protein signatures.

Main Results:

  • High variability exists in emergency department management of febrile infants.
  • C-reactive protein (CRP) and procalcitonin are valuable for risk-stratifying infants.
  • Urine concentration impacts the diagnostic value of pyuria in suspected urinary tract infections (UTI).
  • Novel diagnostics show promise in identifying infants with serious infections.

Conclusions:

  • Urinary tract infection (UTI) is the most common SBI in febrile infants.
  • Procalcitonin and CRP in prediction algorithms help identify low-risk infants.
  • Accurate diagnosis of invasive bacterial infections in infants remains a challenge.
Abstract

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