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Serum phosphate and cognitive function in older men.

Yelena Slinin1,2, Tien Vo3, Brent C Taylor2,3,4

  • 1Department of Nephrology, VA Health Care System, Minneapolis, MN, USA.

International Journal of Geriatric Psychiatry
|March 23, 2017
PubMed
Summary
This summary is machine-generated.

Higher serum phosphate in older men is linked to poorer executive function, but not global cognitive impairment or decline. This study investigated the association between serum phosphate levels and cognitive health in aging men.

Keywords:
cognitive functionmenolderphosphate

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Area of Science:

  • Gerontology
  • Neuroscience
  • Biochemistry

Background:

  • Cognitive impairment and decline are significant concerns in aging populations.
  • Serum phosphate, a key electrolyte, plays roles in various physiological processes, including cellular energy metabolism and signaling pathways relevant to brain function.
  • Previous research has not definitively established the link between serum phosphate levels and cognitive outcomes in older men.

Purpose of the Study:

  • To investigate the association between serum phosphate levels and concurrent cognitive impairment in older men.
  • To determine if serum phosphate is associated with subsequent cognitive decline over time.
  • To examine these associations independently of demographic factors and atherosclerotic risk indicators.

Main Methods:

  • A prospective cohort study involving 5529 men from the Osteoporotic Fractures in Men (MrOS) study.
  • Baseline serum phosphate levels and cognitive function were measured.
  • Cognitive function was re-assessed approximately 4.6 years later using the Modified Mini-Mental State (3MS) Examination for global cognition and Trails B for executive function.

Main Results:

  • Serum phosphate was not associated with cognitive impairment (3MS score) or cognitive decline (change in 3MS score).
  • Higher serum phosphate levels were associated with increased odds of poor executive function (Trails B performance) at baseline (p-trend 0.007).
  • No significant association was found between serum phosphate levels and the decline in executive function over the follow-up period (p-trend 0.22).

Conclusions:

  • Elevated serum phosphate in older men is linked to a higher prevalence of poor executive function.
  • Serum phosphate levels do not appear to be associated with global cognitive impairment or the decline of global or executive cognitive function in this cohort.
  • Further research is warranted to understand the mechanisms underlying the association between serum phosphate and executive function.