Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Typical Model Studies01:30

Typical Model Studies

664
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
664
Anatomy of the Circulatory System02:03

Anatomy of the Circulatory System

100.4K
The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.
100.4K
Overview of Systemic and Pulmonary Circulation01:15

Overview of Systemic and Pulmonary Circulation

12.1K
The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
12.1K
Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

8.5K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
8.5K
Modeling and Similitude01:12

Modeling and Similitude

693
Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
693
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

402
Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
402

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Digoxin With Preserved Echocardiographic Indices in the Interstage Period: A Possible Mechanism to Explain Improved Survival?

Journal of the American Heart Association·2021
Same author

Abnormalities in serum biomarkers correlate with lower cardiac index in the Fontan population.

Cardiology in the young·2017
Same author

Model-Based Comparison of the Normal and Fontan Circulatory Systems-Part II: Major Differences in Performance Characteristics.

World journal for pediatric & congenital heart surgery·2015
Same author

Ultrasonographic imaging of the cervical thoracic duct in children with congenital or acquired heart disease.

Echocardiography (Mount Kisco, N.Y.)·2014
Same author

Model-Based Comparison of the Normal and Fontan Circulatory Systems: Part I: Development of a General Purpose, Interactive Cardiovascular Model.

World journal for pediatric & congenital heart surgery·2014
Same author

Disorders of left ventricular trabeculation/compaction or right ventricular wall formation.

American journal of medical genetics. Part C, Seminars in medical genetics·2013
Same journal

Pioneering Cardiac Surgical Outcomes Research in the Brazilian Amazon: Data Challenges, Methodological Choices, and the Value of First Regional Evidence.

World journal for pediatric & congenital heart surgery·2026
Same journal

Mechanical Mitral Valve Replacement in Patients Under 18 Years of Age.

World journal for pediatric & congenital heart surgery·2026
Same journal

In-Hospital Mortality in Children Undergoing Congenital Heart Surgery in North Brazil: Methodological Considerations on RACHS-1 Interpretation.

World journal for pediatric & congenital heart surgery·2026
Same journal

Acute Severe Left Atrioventricular Valve Regurgitation Secondary to Spontaneous Rupture of Chordae Tendinae in a Patient with Down Syndrome.

World journal for pediatric & congenital heart surgery·2026
Same journal

Integration of the Korean and World Databases for Pediatric and Congenital Heart Surgery: A Model for Global Registry Collaboration.

World journal for pediatric & congenital heart surgery·2026
Same journal

Prostaglandin Administration and Outcomes in Children on Extracorporeal Membrane Oxygenation.

World journal for pediatric & congenital heart surgery·2026
See all related articles

Related Experiment Video

Updated: Mar 5, 2026

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring
06:29

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring

Published on: May 2, 2025

875

Model-Based Comparison of the Normal and Fontan Circulatory Systems-Part III.

Raymond L Watrous1, Alvin J Chin1,2

  • 11 Division of Cardiology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

World Journal for Pediatric & Congenital Heart Surgery
|March 23, 2017
PubMed
Summary
This summary is machine-generated.

Understanding Fontan circulation dynamics is key. New models show respiration and skeletal muscle contraction significantly impact cardiac output during exercise, offering insights into exercise performance limitations.

Keywords:
Fontancardiovascular hemodynamicscomputational modelingexercisehypoplastic left heartlumped-parameter modelingrespirationsingle ventricleskeletal muscle pump

More Related Videos

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.1K
In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K

Related Experiment Videos

Last Updated: Mar 5, 2026

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring
06:29

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring

Published on: May 2, 2025

875
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.1K
In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K

Area of Science:

  • Pediatric Cardiology
  • Computational Fluid Dynamics
  • Cardiovascular Physiology

Background:

  • Current treatments offer limited improvement for Fontan patients' exercise capacity.
  • Existing understanding of factors affecting exercise hemodynamics in Fontan circulation is incomplete.

Purpose of the Study:

  • To develop a computational model of Fontan circulation that accurately reflects exercise hemodynamics.
  • To investigate the impact of respiration and skeletal muscle contraction on cardiac output in Fontan patients.

Main Methods:

  • Rescaled computational models of normal and Fontan patients.
  • Incorporated nonlinear flow-resistance relationship in the total cavopulmonary connection (TCPC).
  • Added respiration and skeletal muscle contraction to the model.

Main Results:

  • Models without respiration failed to match clinical peak exercise cardiac index (CI) values.
  • Dynamic TCPC resistance significantly impacts CI during exercise, especially with respiration.
  • Skeletal muscle contraction most effectively augments cardiac output during peak inspiration.

Conclusions:

  • A comprehensive Fontan model including dynamic TCPC resistance, respiration, and skeletal muscle contraction provides novel insights.
  • These factors are crucial for understanding exercise hemodynamics in Fontan patients.
  • Comparison with normal circulation models highlights key differences in response to physiological challenges.