A Rare Breast Tumor: Dermatofibrosarcoma Protuberans.

Area of Science:

• Oncology
• Dermatopathology
• Surgical Pathology

Background:

• Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive skin tumor.
• DFSP typically affects subcutaneous tissue on proximal extremities and trunk.
• Breast involvement by DFSP is exceptionally uncommon.

Observation:

• A 44-year-old female presented with a large (8x5.5 cm) breast mass.
• Mammography showed a well-defined, lobulated mass with skin involvement.
• Initial biopsy revealed a spindle cell lesion, prompting further investigation.

Findings:

• Macroscopic examination revealed an ulcerated mass with a well-defined, pale solid tumor.
• Microscopic analysis showed monotonous spindle cells in a storiform pattern, with CD34 positivity.
• Histopathology and immunohistochemistry confirmed the diagnosis of dermatofibrosarcoma protuberans.

Implications:

• Accurate diagnosis of DFSP is crucial for appropriate management.
• Complete surgical excision with wide margins is the standard treatment.
• High recurrence rates (20-50%) necessitate vigilant follow-up.