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Updated: Mar 5, 2026
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
A novel network analysis tool to identify relationships between disease states and risks for red blood cell
R Celli1, W Schulz1, J E Hendrickson1,2
1Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
Abstract:
We hypothesized that diagnoses may be associated with alloantibody 'responder' status and examined associations between disease states and alloimmunization. Patients with ≥1 alloantibody and non-alloimmunized controls were analysed. Pearson's coefficients were calculated to determine associations between alloimmunization and diseases; significant correlations were selected to construct a network. Inflammatory disorders and diseases requiring chronic transfusion support were associated with responder status. Mitigation steps may be considered in patients with these disorders.
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