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Related Experiment Video

Updated: Mar 5, 2026

Expression, Purification, and Antimicrobial Activity of S100A12

Expression, Purification, and Antimicrobial Activity of S100A12

Published on: May 13, 2017

S100A6 - focus on recent developments.

Wiesława Leśniak, Tomasz Wilanowski, Anna Filipek

Biological Chemistry

|March 27, 2017

Summary

S100A6, a calcium-binding protein, changes shape upon calcium binding, interacting with various targets. This review details its roles in cell proliferation, signaling pathways, and presence in stem cells and disease fluids.

Area of Science:

Biochemistry
Molecular Biology
Cell Biology

Background:

S100A6 is a calcium-binding protein from the S100 family.
Calcium binding induces conformational changes, increasing S100A6 hydrophobicity and target interaction.
S100A6 is expressed in normal tissues and various tumors, suggesting diverse roles.

Purpose of the Study:

To review novel discoveries on S100A6 targets.
To summarize S100A6 involvement in cellular signaling pathways.
To highlight S100A6 presence in stem/progenitor cells, extracellular matrix, and diseased patient body fluids.

Main Methods:

Literature review of recent studies on S100A6.
Analysis of S100A6 interactions and functions.
Examination of S100A6 expression patterns and locations.

Keywords:

S100 family S100A6 (calcyclin)body fluids pathology stem/progenitor cells tumor

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Last Updated: Mar 5, 2026

Expression, Purification, and Antimicrobial Activity of S100A12

Expression, Purification, and Antimicrobial Activity of S100A12

Published on: May 13, 2017

Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation

Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation

Published on: September 29, 2019

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Published on: July 5, 2019

Main Results:

S100A6 interacts with numerous targets following calcium-induced conformational changes.
S100A6 is implicated in cell proliferation, cytoskeletal dynamics, and tumorigenesis.
Novel findings reveal S100A6's roles in signaling, stem cells, extracellular matrix, and disease biomarkers.

Conclusions:

S100A6 is a versatile protein with significant roles in normal physiology and disease.
Understanding S100A6's diverse functions and targets can inform therapeutic strategies.
S100A6 holds potential as a biomarker in various pathological conditions.