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Related Experiment Video

Updated: Mar 5, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Organs-on-chips: Progress, challenges, and future directions.

Lucie A Low¹, Danilo A Tagle¹

¹National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.

Experimental Biology and Medicine (Maywood, N.J.)

|March 28, 2017

Summary

This summary is machine-generated.

The National Institutes of Health Microphysiological Systems (MPS) program advanced tissue chip technology. This commentary reviews the program's achievements, challenges, and future directions for broader community adoption.

Keywords:

Bioengineering National Institutes of Health induced pluripotent stem cells microfluidics microphysiological systems

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Area of Science:

Biotechnology and Biomedical Engineering
Translational Science
Drug Development and Toxicology

Background:

The National Institutes of Health (NIH) Microphysiological Systems (MPS) program, a collaboration with DARPA and FDA, is concluding its initial funding phase.
The program has significantly contributed to the advancement of tissue chip technology.

Purpose of the Study:

To review the accomplishments of the NIH MPS program in tissue chip development.
To identify challenges encountered and areas for future research.
To outline the future trajectory of the NIH MPS program.

Main Methods:

The commentary synthesizes outcomes from the NIH MPS program, focusing on stem cell differentiation, microfluidic engineering, and multi-organ system development.
It analyzes progress and identifies challenges based on program activities and community feedback.

Main Results:

Tangible advancements in stem cell differentiation and microfluidic engineering for tissue chip creation.
Development of single and multi-organ systems, facilitating broader community acceptance and use of tissue chips.
Identification of key challenges in the field that require further investigation and development.

Conclusions:

The NIH MPS program has successfully driven innovation in tissue chip technology, meeting many initial goals.
Addressing identified challenges is crucial for the continued progress and widespread adoption of MPS.
The program's future direction will focus on sustaining momentum and overcoming remaining hurdles in the field.