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Basics of Sterile Compounding: Biopharmaceutics of Injectable Dosage Forms
1Baxter BioPharma Solutions, Bloomington, Indiana. mjakers356@gmail.com.
International Journal of Pharmaceutical Compounding
|March 28, 2017
Summary
Biopharmaceutics of injectable drugs is reviewed, focusing on absorption, distribution, metabolism, and elimination. Emerging sustained-release systems increase the importance of understanding injectable drug biopharmaceutics for various administration routes.
Area of Science:
- Pharmacology
- Pharmaceutics
- Drug Delivery Systems
Background:
- Biopharmaceutics examines drug product behavior post-administration.
- Intravenous injections bypass absorption, leading to fewer publications compared to other routes.
- Increasing use of sustained- and controlled-release injectable systems necessitates broader biopharmaceutic understanding.
Purpose of the Study:
- To review fundamental biopharmaceutic principles for injectable drugs.
- To discuss factors influencing the pharmacokinetics of injectable medications.
- To highlight the evolving landscape of injectable drug administration routes.
Main Methods:
- Literature review of biopharmaceutic principles.
- Analysis of drug absorption, distribution, metabolism, and elimination (ADME) for injectables.
- Examination of physicochemical and physiological factors impacting injectable drug performance.
Main Results:
- Established principles of ADME are applicable to injectable drugs.
- Physicochemical properties significantly affect injectable drug disposition.
- Physiological factors at the administration site influence drug release and absorption.
Conclusions:
- Understanding injectable drug biopharmaceutics is crucial, especially with advanced delivery systems.
- Factors affecting drug absorption, distribution, metabolism, and elimination require careful consideration for all injectable routes.
- Further research into non-intravenous injectable biopharmaceutics is warranted.
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