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Maternal determinants of renal mass and function in the fetus and neonate

Patrick Brophy1

  • 1University of Iowa Stead Family Children's Hospital, University of Iowa, Iowa City, IA, USA.

Seminars in Fetal & Neonatal Medicine
|March 29, 2017
PubMed

Insights

Maternal health and early life factors significantly influence chronic kidney disease (CKD) risk. Understanding intrauterine determinants of kidney development can enable earlier interventions for lifelong renal health.

Area of Science:

  • Perinatology
  • Nephrology
  • Developmental Biology

Background:

  • Adverse maternal and early gestational issues impact later chronic disease development.
  • Chronic kidney disease (CKD) development serves as a model for early life event impact on renal function.
  • Current focus on CKD treatment is costly and reactive, necessitating a shift towards prevention.

Purpose of the Study:

  • To explore the intrauterine determinants of fetal and neonatal renal mass and function.
  • To provide a foundation for understanding maternal factors influencing kidney development.
  • To highlight the need for earlier intervention strategies in preventing CKD.

Main Methods:

  • Review of existing literature on maternal-fetal interactions and renal development.
  • Analysis of socio-economic, genetic, and environmental factors influencing renal health.
  • Exploration of early life determinants of chronic kidney disease.

Main Results:

  • Early life events, including maternal health and gestational environment, are critical for renal development.
  • Socio-economic and environmental factors significantly modulate CKD risk.
  • Limited understanding exists regarding the specific intrauterine determinants of renal mass and function.

Conclusions:

  • A proactive approach focusing on intrauterine factors is crucial for preventing CKD.
  • Understanding maternal determinants of renal development can guide early intervention strategies.
  • Further research into early life influences is essential for lifelong kidney health and reducing the burden of CKD.

Keywords:
KidneyMaternal/fetal determinantsNeonateRenal mass

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