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Related Experiment Videos

Eucheuma cottonii Sulfated Oligosaccharides Decrease Food Allergic Responses in Animal Models by Up-regulating

Sha-Sha Xu1, Qing-Mei Liu1, An-Feng Xiao1

  • 1College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University , 43 Yindou Road, Xiamen 361021, Fujian, People's Republic of China.

Journal of Agricultural and Food Chemistry
|April 1, 2017
PubMed
Summary

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Eucheuma cottonii sulfated oligosaccharide (ESO) effectively combats food allergies in mice. This seaweed-derived compound reduces allergic reactions by modulating immune cells and decreasing key allergy markers.

Area of Science:

  • Marine Biotechnology
  • Immunology
  • Allergy Research

Background:

  • Food allergies represent a growing global health concern.
  • Current treatments often manage symptoms rather than addressing underlying immune responses.
  • Eucheuma cottonii sulfated oligosaccharide (ESO) presents a potential natural compound for modulating allergic conditions.

Purpose of the Study:

  • To investigate the anti-food allergy activity of Eucheuma cottonii sulfated oligosaccharide (ESO).
  • To elucidate the mechanisms by which ESO affects immune cells involved in allergic responses.
  • To evaluate the therapeutic potential of ESO in a mouse model of food allergy.

Main Methods:

  • ESO was extracted from Eucheuma cottonii via enzymatic degradation and purified using column chromatography.
Keywords:
Eucheuma cottonii sulfated oligosaccharide (ESO)Treg cellsfood allergymast cellsmurine model

Related Experiment Videos

  • In vitro studies utilized RBL-2H3 cells and bone marrow-derived mast cells (BMMCs).
  • In vivo efficacy was assessed in a BALB/c mouse model, with analysis of mast cell protease-1, histamine, specific IgE, interleukin-4 (IL-4), interleukin-13 (IL-13), and regulatory T (Treg) cells via flow cytometry.

    • Main Results:

    • ESO significantly reduced mast cell protease-1 and histamine levels in vivo.
    • Specific IgE levels were inhibited by 77.7% in ESO-treated mice.
    • ESO diminished the production of pro-allergic cytokines IL-4 and IL-13.
    • A notable up-regulation of regulatory T (Treg) cells, by 22.2-97.1%, was observed in response to ESO.
    • ESO treatment led to increased levels of IL-10, associated with Treg cell function.

    Conclusions:

    • Eucheuma cottonii sulfated oligosaccharide (ESO) demonstrates significant anti-food allergy effects.
    • ESO mitigates allergic responses by reducing basophil degranulation and inhibiting key inflammatory mediators.
    • The compound effectively up-regulates regulatory T (Treg) cells, promoting immune tolerance.
    • ESO shows promise as a preventive and therapeutic agent for allergic diseases.