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Related Experiment Videos

Gaining insight into tablet capping tendency from compaction simulation.

Shubhajit Paul1, Changquan Calvin Sun1

  • 1Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127 B Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, United States.

International Journal of Pharmaceutics
|April 1, 2017
PubMed
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Tablet capping, a common manufacturing issue, can be predicted using a compaction simulator. This study reveals that high elastic recovery and radial pressure indicate a risk of capping, guiding better tablet formulation.

Area of Science:

  • Pharmaceutical Manufacturing
  • Materials Science
  • Process Engineering

Background:

  • Tablet capping and lamination remain significant challenges in pharmaceutical manufacturing.
  • Existing knowledge is insufficient to fully prevent these common tablet defects.
  • Developing predictive tools is crucial for optimizing tablet production.

Purpose of the Study:

  • To evaluate a compaction simulator as a predictive tool for tablet capping.
  • To identify key mechanical parameters associated with capping occurrence.
  • To provide insights for designing robust tablet formulations.

Main Methods:

  • Acetaminophen formulations were studied using a compaction simulator.
  • In-die compaction data, including elastic recovery and radial pressure, were systematically analyzed.
Keywords:
CappingCompaction simulationFormulation developmentLaminationMechanical propertyTableting

Related Experiment Videos

  • Correlation between mechanical properties and capping was investigated.

    • Main Results:

    • Tablet capping strongly correlates with high in-die elastic recovery.
    • High Poisson's ratio and radial die-wall pressure are indicative of capping risk.
    • Low tensile strength of tablets is associated with increased capping.

    Conclusions:

    • A compaction simulator can effectively predict tablet capping under manufacturing conditions.
    • Understanding in-die mechanical properties guides the formulation of capping-resistant tablets.
    • This approach aids in developing high-quality pharmaceutical products, especially for challenging APIs.