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Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons
I S Povarov1, R V Kondratenko2, V I Derevyagin2
1Research Center of Neurology, Moscow, Russia. povarovigor@mail.ru.
Bulletin of Experimental Biology and Medicine
|April 1, 2017
Abstract:
Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decrease in this activity. In the examined concentration range (1-8 μM), Selank demonstrated no significant dose-dependence.