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Related Experiment Videos

Adverse Reactions to Biologic Therapy.

Sheenal V Patel1, David A Khan1

  • 1Division of Allergy and Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, F4.206, Dallas, TX 75390-8859, USA.

Immunology and Allergy Clinics of North America
|April 4, 2017
PubMed
Summary

Biologic therapies for inflammatory conditions can cause adverse reactions. Current diagnostic tools are insufficient, necessitating expert management and desensitization strategies for hypersensitivity.

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Area of Science:

  • Immunology and Pharmacology
  • Dermatology and Allergy

Background:

  • Biologic therapies are increasingly used for inflammatory and autoimmune diseases.
  • The expanding use of biologics leads to more frequent adverse reactions.
  • Existing diagnostic methods for hypersensitivity reactions to biologics are inadequate.

Purpose of the Study:

  • To review management strategies for adverse reactions to biologic therapies.
  • To address acute infusion reactions, injection site reactions, and IgE-mediated hypersensitivity.
  • To highlight the role of allergists/immunologists in managing these reactions.

Main Methods:

  • Review of current literature on biologic therapy adverse reactions.
  • Discussion of diagnostic limitations for hypersensitivity.
Keywords:
Biologic agentsDelayed reactionDrug desensitizationInfusion reactionMonoclonal antibodiesOmalizumabRituximab

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  • Outline of management and desensitization protocols.

    • Main Results:

    • Acute infusion and injection site reactions are common.
    • Immediate hypersensitivity reactions can be IgE-mediated.
    • Current diagnostic tests (skin, in vitro) have limitations.

    Conclusions:

    • Management strategies for acute and hypersensitivity reactions are crucial.
    • Desensitization is a viable option for IgE-mediated reactions.
    • Involvement of allergists/immunologists is essential for optimal patient care.