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Hepatocellular carcinoma with intracranial metastasis in a Japanese macaque (Macaca fuscata)
Takako Miyabe-Nishiwaki1, Akihiro Hirata2, Akihisa Kaneko1
1Primate Research Institute, Kyoto University, Aichi, Japan.
Background:
A 23-year-old male Japanese macaque (Macaca fuscata) showed left ptosis, which progressed to exophthalmos.
Methods:
The macaque underwent a clinical examination, CT and MRI, and was euthanized. Necropsy and histopathological examination were performed after euthanasia.
Results:
The CT revealed and MRI confirmed an intracranial mass at the skull base with orbital extension. At necropsy, there were a large hepatic mass and an intracranial mass compressing the left temporal lobe of the brain. Histopathological and immunohistological examinations revealed that the masses were hepatocellular carcinoma (HCC) and a metastatic lesion. In both the primary and metastatic lesions, neoplastic hepatocytes were arranged mainly in a trabecular pattern. Immunohistochemically, the tumor cells were positive for cytokeratin (AE1/AE3 and CAM5.2) and hepatocyte paraffin 1 and negative for cytokeratin 7 and 20 and vimentin.
Conclusion:
To our knowledge, this is the first case report of HCC with intracranial metastasis in a macaque.