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Long Non-Coding RNAs in Cardiac Remodeling.

Shutong Shen¹, Huimin Jiang^2,3, Yihua Bei^4,5

¹Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology

|April 5, 2017

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This summary is machine-generated.

Long non-coding RNAs (lncRNAs) significantly modify cardiac remodeling, impacting heart disease progression. Targeting lncRNA expression offers promising therapeutic strategies for cardiovascular diseases.

Area of Science:

Cardiovascular Biology
Molecular Genetics
Epigenetics

Background:

Cardiac remodeling, a pathological process involving cardiomyocyte hypertrophy, apoptosis, and extracellular matrix changes, underlies cardiovascular disease progression.
Long non-coding RNAs (lncRNAs) are increasingly recognized as critical regulators of cardiac remodeling.
Specific lncRNAs have been linked to various aspects of cardiac remodeling, including hypertrophy, cell loss, and vascular dysfunction.

Purpose of the Study:

To review the role of lncRNAs in cardiac remodeling.
To highlight specific lncRNAs involved in different pathological processes of cardiac remodeling.
To explore the therapeutic potential of modulating lncRNA expression in cardiovascular diseases.

Main Methods:

Literature review of studies investigating lncRNAs in cardiac remodeling.

Keywords:

Apoptosis Cardiac remodeling Hypertrophy Long non-coding RNAs

Related Experiment Videos

Analysis of implicated lncRNAs in cardiac hypertrophy, cardiomyocyte loss, extracellular matrix remodeling, and vascular cell dysfunction.

Synthesis of findings regarding the regulatory functions of lncRNAs in the heart.

Main Results:

Numerous lncRNAs (e.g., Chaer, Chast, Mhrt, CHRF, ROR, H19, MIAT, NRF, APF, CARL, UCA) are implicated in cardiac hypertrophy and cardiomyocyte loss.
Specific lncRNAs (MALAT1, TGFB2-OT1, lincRNA-p21, lnc-Ang362) are involved in vascular endothelial and smooth muscle cell dysfunction and proliferation.
lncRNAs act as dynamic modifiers of the pathological processes in cardiac remodeling.

Conclusions:

lncRNAs play a crucial role in regulating cardiac remodeling and cardiovascular disease progression.
Modulating lncRNA expression, by inhibiting disease-up-regulated or increasing disease-down-regulated lncRNAs, presents a novel therapeutic avenue.
Targeting lncRNAs offers a promising strategy for treating cardiac remodeling and related cardiovascular diseases.