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Gray matter volume changes in chronic subcortical stroke: A cross-sectional study
Qingqing Diao1, Jingchun Liu1, Caihong Wang2
1Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
Neuroimage. Clinical
|April 6, 2017
Summary
Right-sided strokes in right-handed patients show increased gray matter volume (GMV) in motor areas compared to controls. This GMV increase, particularly in the supplementary motor area (SMA), may aid motor recovery after stroke.
Area of Science:
- Neuroscience
- Neurology
- Radiology
Background:
- Subcortical stroke impacts motor function.
- Gray matter volume (GMV) changes after stroke are not fully understood.
- Lesion side and motor recovery may influence brain structure.
Purpose of the Study:
- To investigate the effect of lesion side and motor recovery on GMV differences in chronic subcortical stroke.
- To compare GMV in stroke patients with healthy controls.
- To explore the relationship between GMV changes and motor recovery.
Main Methods:
- Structural MRI data from 97 chronic subcortical stroke patients and 79 healthy controls.
- Voxel-wise gray matter volume (GMV) analysis.
- Comparison of GMV between patients with right-sided lesions, left-sided lesions, and controls.
Main Results:
- Right-lesion patients showed increased GMV in bilateral paracentral lobule (PCL) and supplementary motor area (SMA), and right middle occipital gyrus (MOG) compared to controls.
- Left-lesion patients did not show significant GMV differences.
- GMV increase in the SMA correlated with motor recovery in right-lesion patients.
Conclusions:
- A lesion-side effect on GMV exists in right-handed patients with chronic subcortical stroke.
- Increased GMV in the SMA may play a role in facilitating motor recovery.
- Findings highlight the brain's adaptive plasticity following stroke.