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C-reactive protein and ageing.

Ying Tang1, Erik Fung2, Anping Xu1

  • 1Department of Nephrology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Clinical and Experimental Pharmacology & Physiology
|April 6, 2017
PubMed
Summary
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C-reactive protein (CRP) is an inflammatory biomarker and risk factor in aging-related diseases. It drives inflammation, fibrosis, and impairs cell regeneration, contributing to aging and disease progression.

Area of Science:

  • Biochemistry
  • Immunology
  • Gerontology

Background:

  • C-reactive protein (CRP) is increasingly recognized beyond its role as an inflammatory biomarker.
  • Emerging evidence links CRP to various age-related diseases, including cardiovascular, hypertensive, diabetic, and kidney conditions.
  • CRP's pathogenic roles in diseases like hypertensive complications and diabetic nephropathy are being elucidated.

Purpose of the Study:

  • To review the multifaceted roles of C-reactive protein (CRP) in the aging process.
  • To explore CRP's mechanisms in physiological aging and age-related diseases.
  • To detail CRP's impact on cellular signaling pathways relevant to aging.

Main Methods:

  • Literature review of recent studies on CRP's function and mechanisms.
Keywords:
CRPageingfibrosisinflammationsignalling

Related Experiment Videos

  • Analysis of CRP's involvement in inflammatory and fibrotic pathways.
  • Examination of CRP's effects on cell cycle regulation and aging.

    • Main Results:

    • CRP acts as a pathogenic factor in cardiovascular and kidney diseases.
    • CRP activates key signaling pathways including NF-κB, TGF-β/Smad, and mTOR.
    • CRP impairs cell regeneration by inducing cell cycle arrest and promotes aging via Smad3-dependent mechanisms.

    Conclusions:

    • CRP is a significant contributor to aging and age-related pathologies.
    • Understanding CRP's signaling mechanisms offers therapeutic targets for aging and related diseases.
    • CRP's role extends to cellular processes, impacting regeneration and senescence.