Keratolimbal allograft
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Updated: Sep 14, 2026
Orthotopic Hind Limb Transplantation in the Mouse
Published on: February 12, 2016
Albert Y Cheung1, Edward J Holland
1aCincinnati Eye Institute bUniversity of Cincinnati, Cincinnati, Ohio, USA.
Purpose Of Review:
Keratolimbal allograft (KLAL) transplants limbal tissue attached to a corneoscleral carrier from a cadaveric donor to deliver a large number of stem cells to the recipient. The present article will provide a review of KLAL focusing on the recent literature.
Recent Findings:
Recent findings pertain to tissue selection, immunosuppression and adverse event profiles, and postoperative complications (particularly related to immunologic rejection).
Summary:
KLAL permits the treatment of limbal stem cell deficiency eyes when there is no available living-related or autograft tissue with minimal risk of irreversible toxicity from modern systemic immunosuppression. The prevention of immunologic graft rejection with the use of systemic immunosuppression after KLAL is critical and may require extending systemic immunosuppression treatment longer than previously thought. With vigilant postoperative management, KLAL can allow successful treatment of the most severely diseased eyes.
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