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Pyreneacyl sulfides as a visible light-induced versatile ligation platform

Bryan T Tuten1, Jan P Menzel, Kai Pahnke

  • 1Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Engesserstr. 18, 76128 Karlsruhe, Germany. christopher.barner-kowollik@kit.edu.

Chemical Communications (Cambridge, England)
|April 7, 2017
PubMed
Summary

Researchers developed a new light-activated molecule that creates reactive thioaldehydes. These thioaldehydes can be trapped by other molecules, offering a versatile new platform for chemical reactions.

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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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