Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune Responses in Malaria.

Carole A Long1, Fidel Zavala2

  • 1Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, Maryland 20852.

Cold Spring Harbor Perspectives in Medicine
|April 9, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epitope-selective vaccine designs to elicit protective antibodies against the Plasmodium falciparum circumsporozoite protein.

NPJ vaccines·2026
Same author

Relevance of the antibody Fc fragment and epitope valency in protection against malaria sporozoites.

EMBO reports·2026
Same author

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity.

Nature communications·2026
Same author

Anti-Malaria Antibody Engineering Broadens Recognition Motifs and Reveals New Homotypic Interactions that Enhance Protective Breadth.

bioRxiv : the preprint server for biology·2025
Same author

mRNA delivery of circumsporozoite protein epitope-based malaria vaccines induces protection in a mouse model.

NPJ vaccines·2025
Same journal

The Biology of Malaria Parasite Liver Infection.

Cold Spring Harbor perspectives in medicine·2026
Same journal

The Interaction between Diabetes Mellitus and Tuberculosis: Epidemiology, Screening, and Clinical Management.

Cold Spring Harbor perspectives in medicine·2026
Same journal

New Malaria Prevention Modalities: Long-Acting Interventions Beyond Vaccines.

Cold Spring Harbor perspectives in medicine·2026
Same journal

From Parasite to Pill: Harnessing Biology for Breakthroughs in Antimalarial Drug Discovery.

Cold Spring Harbor perspectives in medicine·2026
Same journal

Malaria Parasite Genomics: Decentralization, Diversification, and Development Goals.

Cold Spring Harbor perspectives in medicine·2026
Same journal

Tuberculosis Infection: Diagnosis and Management.

Cold Spring Harbor perspectives in medicine·2026
See all related articles

Developing effective malaria vaccines is challenging due to the Plasmodium parasite

Area of Science:

  • Immunology
  • Parasitology
  • Vaccinology

Background:

  • Antiparasite immune responses can control or prevent malaria parasite infection at all developmental stages.
  • The biological complexity of Plasmodium, including stage-specific genes and antigen diversity, hinders vaccine development.

Purpose of the Study:

  • To review advances in understanding antiparasite immunity against Plasmodium.
  • To identify challenges and opportunities in developing malaria vaccines and immunotherapies.

Main Methods:

  • Review of accumulated evidence on host immune responses to Plasmodium.
  • Characterization of vaccine candidates and parasite antigens.
  • Identification of biological hurdles in malaria vaccine development.

Related Experiment Videos

Main Results:

  • Significant progress has been made in characterizing vaccine candidates and immune responses over the last 30 years.
  • Key hurdles in malaria vaccine development have been identified.
  • Evidence supports that targeting all Plasmodium developmental stages can control infection.

Conclusions:

  • Inducing host immune responses against all Plasmodium developmental stages is crucial for effective malaria control.
  • The development of a comprehensive malaria vaccine is feasible and essential for malaria eradication programs.