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Cu(II) Coordination Polymers as Vehicles in the A3 Coupling
Edward Loukopoulos1, Michael Kallitsakis1,2, Nikolaos Tsoureas1
1Department of Chemistry, School of Life Sciences, University of Sussex , Brighton BN1 9QJ, United Kingdom.
Inorganic Chemistry
|April 11, 2017
Summary
Benzotriazole-based coordination compounds were synthesized and tested as catalysts for A3 coupling reactions. A specific one-dimensional coordination polymer demonstrated excellent catalytic activity for propargylamine synthesis under mild conditions.
Area of Science:
- Coordination Chemistry
- Catalysis
- Organic Synthesis
Background:
- Benzotriazole derivatives are versatile ligands in coordination chemistry.
- A3 coupling reactions are important for synthesizing propargylamine derivatives.
Purpose of the Study:
- To synthesize and characterize novel benzotriazole-based coordination compounds.
- To evaluate their efficacy as homogeneous catalysts for A3 coupling reactions.
Main Methods:
- Two-step synthesis of coordination compounds from commercially available materials.
- Characterization of eleven distinct copper(II) and zinc(II) complexes.
- Testing catalytic activity in the A3 coupling reaction under a non-inert atmosphere.
Main Results:
- Eleven air-stable benzotriazole-based coordination compounds were successfully synthesized.
- Compound 8, a one-dimensional coordination polymer, exhibited excellent catalytic activity.
- The catalyst demonstrated broad substrate scope in the A3 coupling synthesis of propargylamine derivatives.
Conclusions:
- Novel benzotriazole coordination compounds can be efficiently prepared.
- The developed 1D coordination polymer is a highly effective catalyst for A3 coupling reactions.
- This catalytic system operates efficiently under a non-inert atmosphere, simplifying reaction conditions.