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Squaramide-Sulfonamide Organocatalyst for Asymmetric Direct Vinylogous Aldol Reactions
Takaaki Sakai1, Shin-Ichi Hirashima1, Yoshifumi Yamashita1
1Tokyo University of Pharmacy , Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
The Journal of Organic Chemistry
|April 11, 2017
Abstract:
Asymmetric direct vinylogous aldol reactions of furan-2(5H)-one with aldehydes in the presence of a catalytic amount of novel squaramide-sulfonamide organocatalyst resulted in the corresponding addition products with high to excellent enantioselectivities. This is the first successful report illustrating an example of highly stereoselective reactions using a squaramide-sulfonamide organocatalyst.