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DRUG-INDUCED ORAL ULCERATIONS: CASE REPORT
Acta Clinica Croatica
|April 11, 2017
Summary
This case study highlights oral ulcerations in a patient with chronic lymphocytic leukemia. The ulcerations were potentially drug-induced, possibly by allopurinol, and the patient later died from sepsis.
Area of Science:
- Oral Medicine
- Hematology
- Dermatology
Background:
- A 70-year-old patient presented with multiple oral ulcerations.
- The patient had a complex medical history including chronic lymphocytic leukemia (CLL), hypogammaglobulinemia, chronic renal insufficiency, asthma, hypertension, gastritis, and prostate hyperplasia.
Observation:
- Multiple oral ulcerations, approximately 0.5 cm in diameter, were observed on the left buccal mucosa and gingiva.
- The oral lesions' severity correlated with increased doses of allopurinol and chlorambucil, and improved with dose reduction.
Findings:
- Differential diagnoses for the oral ulcerations included drug-induced lesions, paraneoplastic pemphigus, viral, fungal, bacterial infections, and neutropenic ulcers.
- Allopurinol was suspected as the causative agent due to its known association with adverse skin reactions.
Implications:
- This case underscores the importance of considering drug-induced oral ulcerations in patients with complex comorbidities.
- Prompt identification and management of drug-related adverse events are crucial, although this patient ultimately succumbed to sepsis, pneumonia, and multiorgan failure.