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Lichenoid and interface dermatoses.

Alejandro A Gru1, Andrea L Salavaggione2

  • 1Department of Pathology & Dermatology, University of Virginia, Charlottesville, VA, Unitee States.

Seminars in Diagnostic Pathology
|April 12, 2017
PubMed
Summary
This summary is machine-generated.

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Lichenoid and interface dermatitis involve basal cell damage via apoptosis. This pattern, characterized by inflammation at the dermal-epidermal junction, includes conditions like lichen planus and lupus erythematosus.

Area of Science:

  • Dermatology
  • Histopathology
  • Immunology

Background:

  • Lichenoid and interface dermatitis are terms frequently used interchangeably.
  • They describe an inflammatory pattern characterized by basal keratinocyte damage in the epidermis.
  • This damage is primarily understood as apoptosis, or programmed cell death.

Purpose of the Study:

  • To explain the histological characteristics of lichenoid/interface dermatitis.
  • To discuss the mechanism of basal cell damage, identifying it as apoptosis.
  • To review common dermatoses exhibiting this inflammatory pattern.

Main Methods:

  • Histological examination of skin biopsies.
  • Review of clinical and pathological features of various dermatoses.
Keywords:
Erythema multiformeGraft versus host diseaseLichen planusLupus erythematosus

Related Experiment Videos

  • Literature review on the mechanisms of basal cell damage in dermatological conditions.

    • Main Results:

    • The defining feature is basal keratinocyte apoptosis.
    • A superficial dermal infiltrate of lymphocytes and histiocytes is common.
    • This infiltrate often obscures the dermal-epidermal junction.

    Conclusions:

    • Lichenoid/interface dermatitis is a histopathological pattern defined by basal cell apoptosis.
    • Common conditions include lichen planus, lupus erythematosus, dermatomyositis, erythema multiforme, graft-versus-host disease, and fixed drug reactions.
    • Understanding this pattern aids in diagnosing various dermatological conditions.