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A combination strategy using two novel cerium-based nanocomposite affinity probes for the selective enrichment of
Xing-Yu Long1, Zi-Jin Zhang, Jia-Yuan Li
1State Key Laboratory of Analytical Chemistry for Life Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry & Chemical Engineering and Center of Materials Analysis, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, P. R. China. hzlian@nju.edu.cn.
Chemical Communications (Cambridge, England)
|April 13, 2017
Abstract:
This work presents a sequential enrichment protocol, based on two self-designed cerium-based nanocomposite affinity probes, which not only can effectively separate phosphopeptides from non-phosphopeptides but can also selectively differentiate mono- and multi-phosphopeptides for direct matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF MS) analysis.