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Updated: Jul 21, 2026

Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
General Approaches to Structurally Diverse Isocyanoditerpenes
Mary Elisabeth Daub1, Philipp C Roosen1, Christopher D Vanderwal1
1Department of Chemistry, University of California , 1102 Natural Sciences II, Irvine, 92697-2025 California, United States.
Abstract:
Since their discovery in the 1970s, the striking architectures and the unusual isonitrile functional groups of the isocyanoterpenes have attracted the interest of many organic chemists. The more recent revelation of their potent in vitro antiplasmodial activity sparked new endeavors to synthesize members of this family of secondary metabolites. In this Synopsis, we discuss three distinct strategies that each address multiple structurally different members of the isocyanoterpenes, ending with some of our group's recent contributions in this area.
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