Novel method for standard addition signal analysis in voltammetry.

Area of Science:

• Electroanalytical Chemistry
• Analytical Method Development
• Voltammetric Techniques

Background:

• Standard addition analysis is a common technique in voltammetry for accurate quantification.
• Traditional standard addition methods can be subjective and time-consuming.
• Automation in analytical chemistry is crucial for improving efficiency and reproducibility.

Purpose of the Study:

• To introduce a fully automated standard addition analysis procedure in voltammetry.
• To develop a method based on the slope of the peak at the inflection point (SSAA).
• To eliminate subjective user decisions in the standard addition process.

Main Methods:

• Development of the slope of the peak at the inflection point (SSAA) algorithm.
• Testing with simulated data to evaluate the algorithm's performance.
• Experimental validation using differential pulse anodic stripping voltammetry (DPASV) for Pb(II), Cd(II), and Tl(I) detection.

Main Results:

• The SSAA procedure demonstrated good accuracy and precision across all tested analytes.
• DPASV measurements of Pb(II) and Cd(II) on RAgABE showed excellent results.
• Analysis of Tl(I) on BiABE confirmed the method's perfect reproducibility.

Conclusions:

• The proposed SSAA method provides a robust, automated, and objective approach to standard addition analysis in voltammetry.
• This technique is suitable for accurate and reproducible quantification of heavy metals.
• The SSAA method offers a significant advancement over traditional, subjective standard addition protocols.