Related Experiment Videos
[Metastatic brain tumor originating from the cardiac sarcoma]
J Sasaki1, N Hayashi, S Nakamura
1Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan.
Insights
This case study reports a rare instance of malignant fibrous histiocytoma with brain and heart metastasis. The patient presented with neurological symptoms and rapidly progressing heart failure, ultimately succumbing to systemic disease.
Area of Science:
- Oncology
- Neuropathology
- Cardiovascular Pathology
Background:
- Malignant fibrous histiocytoma (MFH) is a rare soft tissue sarcoma.
- Cerebral and cardiac involvement by MFH is exceptionally uncommon.
- Metastatic spread of MFH typically occurs to the lungs, lymph nodes, and bone.
Abstract:
A 39-year-old woman had suddenly onset of headache, aphasia and right hemiparesis. CT scan revealed a mass lesion in the left parieto-temporal lobe. The brain tumor was resected twice. But, heart tumor could not be resected because congestive heart failure progressed rapidly. At last, she succumbed to systemic metastasis at 4 months after the onset of symptoms. At autopsy, tumors were found to be localized in left atrium of the heart, left parietal lobe, bilateral occipital lobe of the brain, pancreas, liver and stomach. Histological examination was diagnosed as a malignant-fibrous-histiocytoma. Review of the literature reveals no other case with cerebral metastasis of malignant-fibrous-histiocytoma.