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Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration
Alessandra Bari1, Nora Bloise2, Sonia Fiorilli1
1Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
Acta Biomaterialia
|April 17, 2017
Summary
Copper-doped mesoporous bioactive glass (MBG) nanoparticles demonstrate potent antibacterial activity and biofilm inhibition. This multifunctional material shows promise for preventing infections and treating bone defects.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Nanotechnology
Background:
- Mesoporous bioactive glasses (MBGs) are of increasing interest for their antibacterial and osteogenic properties.
- Modifying MBGs with ions can enhance their biological functions.
Purpose of the Study:
- To synthesize copper-doped mesoporous bioactive glass (Cu-MBG) nanoparticles.
- To evaluate the antibacterial and anti-biofilm efficacy of Cu-MBG.
Main Methods:
- One-pot ultrasound-assisted sol-gel synthesis of SiO2-CaO MBG doped with copper ions.
- Characterization of surface area, pore size, and ion release.
- In vitro testing of antibacterial activity against E. coli, S. aureus, S. epidermidis.
- Assessment of biofilm inhibition and dispersion.
Main Results:
- Cu-MBG (2%mol.) exhibited high surface area (550 m²/g) and uniform mesopores (2.6 nm).
- Sustained release of Cu²⁺ ions was observed.
- Cu-MBG and its extracts showed significant antibacterial effects and inhibited/dispersed S. epidermidis biofilm.
Conclusions:
- The developed Cu-MBG nanoparticles possess excellent bioactivity and antimicrobial properties.
- This multifunctional material offers a promising alternative to antibiotics for bone defect treatment and infection prevention.