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Related Experiment Videos

Parenteral Nutrition and Lipids.

Maitreyi Raman1, Abdulelah Almutairdi2, Leanne Mulesa3

  • 1Faculty of Medicine, University of Calgary, G055 3330 Hospital Drive, Calgary, AB T2N 4N1, Canada. mkothand@ucalgary.ca.

Nutrients
|April 20, 2017
PubMed
Summary

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Intravenous lipid emulsions (IVLE) are crucial for parenteral nutrition, offering benefits beyond basic nutrition. Newer formulations like olive/soy-based lipids show improved outcomes and reduced inflammation compared to traditional soybean oil lipids.

Area of Science:

  • Biochemistry
  • Clinical Nutrition
  • Pharmacology

Background:

  • Lipids are vital for physiological functions.
  • Soybean oil lipid emulsions have been standard in parenteral nutrition for decades.
  • Intravenous lipid emulsions (IVLE) reduce dextrose dependence and prevent essential fatty acid deficiency.

Purpose of the Study:

  • To review the history and composition of IVLE.
  • To discuss different generations of IVLE.
  • To outline lipid selection variables and IVLE complications.

Main Methods:

  • Literature review of IVLE history, composition, and clinical applications.
  • Analysis of emerging research on alternative lipid formulations.
  • Examination of factors influencing IVLE selection and complication management.
Keywords:
intravenous Lipid Emulsionslipidsparenteral nutrition

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Main Results:

  • Soybean oil-based IVLE have been historically dominant.
  • Alternative and combination lipid formulations (e.g., olive/soy, soy/MCT/olive/fish oil) offer advantages over traditional soybean oil.
  • These newer lipids exhibit reduced inflammation, immune modulation, higher antioxidant content, decreased cholestasis risk, and improved outcomes in specific patient groups.

Conclusions:

  • The evolution of IVLE has led to formulations with enhanced therapeutic properties.
  • Careful selection of IVLE is crucial for optimizing patient outcomes.
  • Understanding and managing IVLE complications is essential for safe and effective parenteral nutrition.