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Total Synthesis of Lamellarin D Trimethyl Ether, Lamellarin D, and Lamellarin H
Dhanaji M Lade1,2, Amit B Pawar1, Prathama S Mainkar1
1Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Hyderabad 500007, India.
The Journal of Organic Chemistry
|April 20, 2017
Abstract:
Total syntheses of three different lamellarins have been accomplished using a Ru(II)-catalyzed (3 + 2) annulation strategy to construct the central pyrrole ring. The striking features of this synthesis are the use of PEG-400 as a green solvent for the (3 + 2) annulation reaction and multiple catalytic reactions with excellent overall yield. The present route also enables the synthesis of various lamellarin analogues devoid of a B ring.