Related Experiment Videos
ALK protein expression in pulmonary adenocarcinoma of Tunisian patients
Amira Toumi Arfaoui1, Ahlem Blel1, Raoudha Aloui1
1a Department of Pathology, Charles Nicolle Hospital , University of Tunis El Manar , Tunis , Tunisia.
Background:
It is now necessary to determine ALK status in order to use targeted therapy.
Aim:
herein, we assess immunohistochemical profile of ALK protein in a series of Tunisian patients with pulmonary adenocarcinoma.
Materials And Methods:
ALK protein expression was studied applying the D5F3 antibody with a fully automated Ventana CDx technique on a series of 19 patients.
Results:
Positive ALK expression was found in one case (5.2%) corresponding to a papillary adenocarcinoma which showed a strong granular and homogenous cytoplasmic staining. The patient was a 30-years-old woman.
Conclusion:
The frequency of positive ALK expression based on immunohistochemistry in our series was similar to that reported in the world literature.