Related Experiment Video
Updated: Aug 12, 2026

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
Published on: February 17, 2011
Variation in Adult Traumatic Brain Injury Outcomes in the United States
Nathaniel H Greene1, Mary A Kernic, Monica S Vavilala
1Department of Anesthesiology and Pain Medicine, School of Medicine (Drs Greene and Vavilala), Department of Epidemiology, School of Public Health (Drs Kernic and Rivara), Department of Pediatrics, School of Medicine (Drs Vavilala and Rivara), and Harborview Injury Prevention and Research Center (Drs Greene, Kernic, Vavilala, and Rivara), University of Washington, Seattle. Nathaniel Greene is now affiliated with Duke University.
State-level variations in acute care hospitalization significantly impact outcomes for adults with traumatic brain injury (TBI). Inpatient mortality risk varied by 40% and rehabilitation discharge by over 100% between states.
Area of Science:
- Trauma care research
- Public health policy
- Healthcare quality improvement
Background:
- Traumatic brain injury (TBI) is a significant cause of mortality and long-term disability.
- Outcomes for TBI patients can vary based on healthcare access and quality.
- Understanding state-level disparities in TBI care is crucial for improving patient outcomes.
Purpose of the Study:
- To assess the variation in inpatient mortality and discharge to rehabilitation among adult patients with moderate to severe TBI across different US states.
- To identify the extent of disparities in acute care hospitalization outcomes for TBI patients.
Main Methods:
- Retrospective cohort study utilizing State Inpatient Databases from the Healthcare Cost and Utilization Project (HCUP).
- Analysis included 95,546 adult patients (≥18 years) with moderate or severe TBI admitted to acute care hospitals in 21 US states in 2010.
- Key outcome measures were inpatient mortality and discharge disposition to inpatient rehabilitation.
Main Results:
- Significant state-level variation was observed in inpatient mortality, with adjusted risks differing by up to 40%.
- The adjusted risk of discharge to inpatient rehabilitation varied by over 100% among the states studied.
- Patient age, injury severity, and insurance status were identified as significant factors influencing both outcomes.
Conclusions:
- Clinically significant state-to-state variations exist in inpatient mortality and rehabilitation discharge following TBI, even after adjusting for known factors.
- Further research is needed to identify the underlying causes of these disparities.
- Standardizing TBI treatment across the US could improve patient outcomes and reduce healthcare variations.

