A Ratiometric and near-Infrared Fluorescent Probe for Imaging Cu2+ in Living Cells and Animals
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Rui Guo1, Qiuan Wang2, Weiying Lin3,4
1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, 410082, People's Republic of China.
Abstract:
We have rationally constructed a novel ratiometric and near-infrared Cu2+ fluorescent probe based on a tricarbocyanine chromophore. The new probe NIR-Cu showed a ratiometric fluorescent response to Cu2+ with a large emission wavelength shift (up to 142 nm) in the far-red to near-infrared region. The probe also displayed a large variation in the fluorescence ratio (I636/I778) to Cu2+ species with high sensitivity and selectivity. Additionally, the developed probe NIR-Cu was suitable for fluorescence imaging of Cu2+ in living cells and mice.
