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The prognostic value of B7-H6 protein expression in human oral squamous cell carcinoma
Jiongke Wang1, Xin Jin2, Jiajia Liu1
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Objectives:
To investigate the expression and prognostic value of B7-H6 protein in oral squamous cell carcinoma tissues.
Materials And Methods:
A total of 50 oral squamous cell carcinoma samples, 10 oral leukoplakia (OLK) samples, and 17 normal controls were included in the analysis. The expression of B7-H6 in oral squamous cell carcinoma, OLK, and normal controls was evaluated by immunohistochemical assay.
Results:
The B7-H6 protein expression was significantly higher in oral squamous cell carcinoma tissues than that in normal oral mucosa. Furthermore, a significant relationship was found between the expression of B7-H6 and differentiation, but not with age, sex, tumor size, lymph metastasis, clinical stage, or recurrence. Further, the survival curves showed that B7-H6 was an independent prognostic factor of overall survival and disease-free survival in oral squamous cell carcinoma. Moreover, multivariate survival analysis by COX proportional hazard regression model revealed that the recurrence, differentiation, and expression of B7-H6 were related to the prognosis. Lastly, we verified the prognostic value of B7-H6 in oral squamous cell carcinoma.
Conclusions:
B7-H6 may represent a new prognostic marker for oral squamous cell carcinoma.
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