Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols
Katharina Plasch1, Verena Resch1, Julien Hitce2
1Department of Chemistry, Organic & Bioorganic Chemistry University of Graz Heinrichstrasse 28A-8010 Graz Austria.
Abstract:
In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o-benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and polyphenols possessing antioxidant properties. o-Hydroxycarboxylic acid products were obtained with perfect regioselectivity, in moderate to excellent yields. The applicability of this method was proven by the regioselective bio-carboxylation of resveratrol on a preparative scale with 95% yield.
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