[NESFATIN-1 ACTIVITY IN PATIENTS WITH ESSENTIAL HYPERTENSION AND PREDIABETES, TYPE 2 DIABETES]

Essential hypertension (EH) is one of the important problems and comorbidity negatively affects the prognosis of the disease. Substantial thing is investigation of metabolic substances that influence the carbohydrate profile. Aim - investigation of the nesfatin-1 activity in patients with Essential hypertension and prediabetes/type2 diabetes. 83 patients with EH were examined and divided into groups according to dysglicemia and abdominal obesity. Significant increasing of nesfatin-1 in patients with EH 7,81±0,26 ng/ml was found comparing to controls 4,54±0,13 ng/ml, p<0,05. In patients with EH with obesity, without dysglicemia level of nesfatin-1 was higher than in obese ones (8,31±0,19 ng/ml, 7,44±0,13 ng/ml correspondebtly (p=0,003)). In patients with EH and dysglicemia the tendency to decreasing of nesfatin in case of accompanied obesity was found. Correlation of nesfatin-1 and systolic blood pressure (r=0,34, p<0,05) was revealed in patients with EH, abdominal obesity without dysglicemia. Increasing of nesfatin-1 in EH comparing to controls was found. Correlations of nesfatin-1 with carbohydrate profile components showed possible involvement of nesfatin-1 in carbohydrate disorders. Controversies of nesfatin-1 data in patients with EH, dysglicemia, obesity, possibly, connected with polymorbidity and needs further investigation.