Related Experiment Video
Updated: Mar 3, 2026

11:22
Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
18.0K
Induced membrane technique for treating tibial defects gives mixed results
The Bone & Joint Journal
|April 30, 2017
Summary
The Masquelet technique showed limited success in treating tibial bone defects, resulting in a low union rate and a high incidence of infection, necessitating amputation in some cases.
Area of Science:
- Orthopedic surgery
- Bone reconstruction techniques
Background:
- Segmental tibial bone loss presents a significant reconstructive challenge.
- The Masquelet technique is a method for inducing bone regeneration in large bone defects.
Purpose of the Study:
- To evaluate the clinical outcomes of the Masquelet technique for treating segmental tibial bone loss.
- To assess the rates of bony union and infection associated with this technique.
Main Methods:
- Retrospective case series of 12 patients with tibial bone defects treated with the Masquelet technique between 2010 and 2015.
- Mean follow-up of 675 days, recording union, infection, and amputation rates.
- Patients had mean defect length of 5.8 cm, with 11 having open fractures.
Main Results:
- Bony union was achieved in only 5 out of 12 patients.
- Five patients experienced infectious complications, with two requiring amputation due to severe infection.
- The mean interval between surgical stages was 57 days.
Conclusions:
- The Masquelet technique demonstrated a relatively low efficacy in achieving bony union for segmental tibial defects in this patient cohort.
- The technique was associated with a high rate of infectious complications, highlighting potential risks.
- Further research may be needed to optimize this technique or explore alternative treatments for extensive bone loss.

