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Updated: Mar 3, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Medical table: A major tool for antimicrobial stewardship policy
P-M Roger1, E Demonchy1, K Risso1
1Infectiologie, université de Nice Sophia-Antipolis, hôpital de l'Archet, centre hospitalier universitaire de Nice, 151, route de St-Antoine, 06202 Nice, France.
Implementing standardized antibiotic guidelines and continuous monitoring significantly reduced infection-related morbidity and mortality. This approach enhances antimicrobial stewardship and patient outcomes in infectious disease management.
Area of Science:
- Infectious Diseases
- Clinical Practice
- Antimicrobial Stewardship
Background:
- Infectious diseases present complex challenges due to varied clinical presentations, pathogens, and antimicrobial resistance.
- Heterogeneous clinical practices hinder the effective evaluation of treatment strategies.
- A departmental medical table has been utilized since 2005 to monitor medical activity.
Purpose of the Study:
- To develop and implement standardized antibiotic guidelines.
- To continuously evaluate the observance and impact of these guidelines on patient outcomes.
- To assess the effect on morbidity, mortality, and adverse events associated with infectious diseases.
Main Methods:
- A 10-year analysis of over 10,000 hospitalizations was conducted using a departmental medical table.
- Therapeutic practices were observed, leading to the creation of internal antibiotic guidelines.
- Continuous evaluation focused on guideline adherence, infection-related morbidity and mortality, antibiotic adverse effects, hospital stay duration, intensive care unit (ICU) utilization, and mortality rates.
Main Results:
- The analysis revealed a simplification of antibiotic therapies.
- A significant reduction in infection-related morbidity and mortality was observed.
- The implementation of guidelines and monitoring led to improved patient outcomes.
Conclusions:
- The departmental medical table is a crucial tool for effective antimicrobial stewardship.
- Standardized antibiotic guidelines and continuous evaluation yield sustained benefits for patients with infectious diseases.
- This integrated approach improves patient care and reduces the burden of infectious diseases.
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