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Updated: Jul 31, 2026

Engineering and Evolution of Synthetic Adeno-Associated Virus (AAV) Gene Therapy Vectors via DNA Family Shuffling
Published on: April 2, 2012
A reply to Avery and Hakkert
1a University of North Carolina , Chapel Hill , N.C. , 27514 , USA.
Abstract:
Udry et al., 1 while analysing the variations in observed birth rates, found that the usual binomial model variance underestimates the actual variance of birth rates. Avery and Hakkert's 2 analysis offers some help in interpreting these results. Also, it clarifies one possible explanation given by Udry et al., regarding the heterogeneous populations. However, we show below that the narrow approach taken by Avery and Hakkert is difficult to apply to general situations and perhaps leads them to make a number of inappropriate statements.
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