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Updated: Mar 3, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

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Roles of platelet-derived growth factor in vascular calcification

Liu Ouyang1,2, Kun Zhang1,2, Jie Chen2,3

  • 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Journal of Cellular Physiology
|May 4, 2017
PubMed

Insights

Vascular calcification (VC) is a complex process accelerated by platelet-derived growth factor (PDGF). Understanding PDGF

Area of Science:

  • Cardiovascular Biology
  • Vascular Biology
  • Biomedical Research

Background:

  • Vascular calcification (VC) is common in aging, hypertension, chronic kidney disease (CKD), and diabetes.
  • VC is an active process involving complex mechanisms of calcium deposition in blood vessels.
  • Current therapies for VC are limited due to its complicated pathogenesis.

Purpose of the Study:

  • To review the role of platelet-derived growth factor (PDGF) in vascular calcification.
  • To identify PDGF as a potential therapeutic target for VC.

Main Methods:

  • Literature review focusing on PDGF's involvement in VC.
  • Analysis of mechanisms by which PDGF influences vascular homeostasis.

Main Results:

  • PDGF acts as a mitogen and chemoattractant, disrupting vascular homeostasis.
  • PDGF contributes to VC by inducing inflammation, oxidative stress, and phenotype transition.

Conclusions:

  • PDGF plays a significant role in accelerating vascular calcification.
  • Targeting PDGF may offer a novel therapeutic strategy for treating VC.

Keywords:
osteogenic phenotypeplatelet-derived growth factorvascular calcificationvascular smooth muscle cell differentiation

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