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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
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Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Multifocal Ocular Surface Squamous Neoplasia.

Swati Singh1, Ruchi Mittal, Suryasnata Rath

  • 1*Ophthalmic Plastics, Orbit and Ocular Oncology Services, and †Dalmia Ophthalmic Pathology Service, L V Prasad Eye Institute, Bhubaneswar, India.

Ophthalmic Plastic and Reconstructive Surgery
|May 5, 2017
PubMed
Summary
This summary is machine-generated.

Multifocal ocular surface squamous neoplasia can be effectively treated with surgery and topical mitomycin C when immunotherapy fails. This approach led to a complete tumor-free outcome in a refractory case.

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Area of Science:

  • Ophthalmology
  • Oncology

Background:

  • Ocular surface squamous neoplasia (OSSN) is a premalignant lesion of the conjunctiva.
  • Multifocal OSSN presents a therapeutic challenge, often requiring multimodal treatment strategies.

Observation:

  • A 64-year-old female presented with multifocal OSSN involving the limbus and tarsal conjunctiva.
  • Initial treatment with subconjunctival interferon alpha 2b (IFN alpha 2b) showed a poor response.

Findings:

  • Excision of the limbal lesion revealed squamous cell carcinoma in situ.
  • Topical mitomycin C 0.04% demonstrated a dramatic response in the refractory tarsal lesion.
  • A multimodal approach combining excision and topical mitomycin C resulted in a complete tumor-free status at one year.

Implications:

  • Multimodal therapy, including surgical excision and topical mitomycin C, is a viable and effective treatment for multifocal ocular surface squamous neoplasia refractory to immunotherapy.
  • This case highlights the potential of topical mitomycin C as a salvage therapy for advanced OSSN.