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Lethal Giant Lineage Tracing: Mutating Locally, Acting Globally.
Aslam Abbasi Akhtar1, Hannah Park1, Joshua J Breunig2
1Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Neuron
|May 5, 2017
Summary
Understanding how radial glia progenitors generate neurons and glia is key to neocortical development. Lgl1 plays crucial cell-intrinsic and global roles in this process, as shown by lineage tracing.
Area of Science:
- Neuroscience
- Developmental Biology
- Cell Biology
Background:
- Neocortical development relies on precise generation of neurons and glia from radial glia progenitors.
- The underlying mechanisms controlling this deterministic cell production remain largely unknown.
Purpose of the Study:
- To investigate the functions of Lgl1 in neocortical development.
- To elucidate the cell-intrinsic and global roles of Lgl1 in regulating progenitor cell behavior.
Main Methods:
- Utilized Mosaic Analysis with Double Markers (MADM)-based lineage tracing.
- Employed sophisticated genetic techniques to track cell fates and behaviors.
Main Results:
- Demonstrated critical cell-intrinsic functions for Lgl1 in progenitor cells.
- Revealed global functions of Lgl1 impacting broader developmental processes.
- Provided insights into the regulation of neuron and glia production.
Conclusions:
- Lgl1 is essential for proper neocortical development.
- Lgl1 acts through both cell-autonomous and non-cell-autonomous mechanisms.
- This study clarifies key regulators of progenitor cell fate during brain development.
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