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Updated: Mar 3, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

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Dissecting the roles of the androgen receptor in prostate cancer from molecular perspectives

Jieping Hu1, Gongxian Wang1, Ting Sun1

  • 1Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|May 6, 2017
PubMed

Insights

Androgen receptor signaling is key in prostate cancer. Understanding its alterations, like mutations and variants, is crucial for treating advanced and castration-resistant prostate cancer effectively.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Androgen receptor (AR) signaling is central to prostate cancer (PC) progression.
  • Androgen deprivation therapy (ADT) is a standard treatment for advanced PC, targeting AR signaling.
  • The development of castration-resistant prostate cancer (CRPC) highlights AR alterations.

Purpose of the Study:

  • To review the molecular mechanisms of AR alterations in PC.
  • To explore AR variant formation, translocation, and functional changes.
  • To provide insights into combating advanced and CRPC.

Main Methods:

  • Literature review of AR signaling in prostate cancer.
  • Analysis of AR mutation, variant formation, and cellular distribution.
  • Examination of protein modification and pathway interactions affecting AR.

Main Results:

  • AR alterations, including mutations and variants, are key to CRPC development.
  • AR translocation and altered function are mediated by protein modifications and pathway crosstalk.
  • AR plays a multifaceted role in both hormone-sensitive and castration-resistant PC.

Conclusions:

  • Understanding AR molecular alterations is vital for developing novel therapeutic strategies.
  • Targeting AR pathway modifications and interactions may overcome CRPC resistance.
  • Further research into AR's molecular landscape can lead to improved PC management.
Keywords:
Androgen receptorcell signalsdimerizationtranslocationvariants

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