Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

6.4K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.4K
Papillary Dermis01:11

Papillary Dermis

6.4K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.4K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.9K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

4.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.0K
Burn Injuries01:22

Burn Injuries

4.8K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
4.8K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

DERMATOSURGERY ROUNDS: THE DOUBLE ROTATION (YIN-YANG) FLAP AS BASIC WEAPON IN THE FIGHT AGAINST KERATINOCYTE CANCER OF THE SCALP.

Georgian medical news·2026
Same author

SECONDARY AMINO GROUPS IN ACE INHIBITORS/CALCIUM CHANNEL BLOCKERS, ANTIARRHYTHMICS AND ANTICOAGULANTS AS DONORS FOR DRUG RELATED PHOTOTOXICITY/CARCINOGENICITY: NUTRITIONAL NITROSOGENESIS AS SUBSTANTIAL/ADDITIONAL COFACTOR FOR SKIN CARCINOGENESIS.

Georgian medical news·2026
Same author

Bilateral large perilabial/perineal acquired kissing hemangiomas.

Wiener medizinische Wochenschrift (1946)·2026
Same author

DERMATOLOGIC SURGERY ROUNDS: RECONSTRUCTIVE SURGERY EMPLOYING THE SHARK ISLAND FLAP FOR BASAL CELL CARCINOMA AFFECTING THE NASAL ALA.

Georgian medical news·2025
Same author

POSTTRAUMATIC SUBUNGUAL ACRAL NODULAR MELANOMA WITH BONE INFILTRATION TREATED VIA AMPUTATION OF THE DISTAL AND MIDDLE PHALANX: DESCRIPTION OF A CASE AND UPDATE ON THE TOPIC.

Georgian medical news·2025
Same author

"DERMATOLOGIC SURGERY (GNP) GROUND AND POUND"- EXTENDABLE PLASTIC SURGERY WITH PRIMARY WOUND CLOSURE AS OPTIMAL TREATMENT OPTION FOR MIDDLE-SIZED CONGENITAL DYSPLASTIC NEVUS OF THE BACK OF AN 8-YEAR-OLD BOY.

Georgian medical news·2025
Same journal

NON-PHARMACOLOGICAL INTERVENTIONS FOR RESTLESS LEG SYNDROME IN HEMODIALYSIS PATIENTS: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.

Georgian medical news·2026
Same journal

CLINICAL RESULTS OF DELORME'S AND ALTEMEIER'S PROCEDURES IN RECTAL PROLAPSE.

Georgian medical news·2026
Same journal

EVALUATION OF GEORGIAN MEDICAL DOCTORS' RESEARCH EXPERIENCE AND PERCEPTIONS TOWARD COLLABORATIVE RESEARCH WITH UNIVERSITIES.

Georgian medical news·2026
Same journal

PSYCHOLOGICAL ASPECTS OF USING SUGGESTIVE METHODS IN COGNITIVE-BEHAVIORAL THERAPY.

Georgian medical news·2026
Same journal

MORPHOLOGY AND PREVALENCE OF C-SHAPED CANALS IN MANDIBULAR FIRST MOLARS OF AN IRAQI KURDISTAN REGION POPULATION: A CONE-BEAM COMPUTED TOMOGRAPHY ASSESSMENT.

Georgian medical news·2026
See all related articles

Related Experiment Video

Updated: Mar 2, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

13.0K

APLASIA CUTIS CONGENITA TYPE I - A CASE SERIES.

U Wollina1, A Chokoeva1, Sh Verma1

  • 1Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; Onkoderma - Policlinic of Dermatology and Dermatologic Surgery, Sofia, Bulgaria; Nirvana Skin Clinic, Vadodara, Gujarat, India; Medical Institute of MVR, Department of Dermatology and Venereology, Sofia, Bulgaria; Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.

Georgian Medical News
|May 9, 2017
PubMed
Summary
This summary is machine-generated.

Aplasia Cutis Congenita type I, a rare skin defect, was successfully treated conservatively in five infants. This approach led to complete wound closure, though skin appendages did not regenerate.

More Related Videos

Microscopic Replantation of Penile Glans Amputation Due to Circumcision
07:28

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

Published on: June 3, 2022

25.8K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K

Related Experiment Videos

Last Updated: Mar 2, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

13.0K
Microscopic Replantation of Penile Glans Amputation Due to Circumcision
07:28

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

Published on: June 3, 2022

25.8K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K

Area of Science:

  • Dermatology
  • Pediatrics
  • Genetics

Background:

  • Aplasia Cutis Congenita (ACC) is a rare congenital disorder characterized by skin and soft tissue absence, with varied subtypes.
  • ACC Type I is the nonsyndromic form, often presenting as isolated scalp defects.

Observation:

  • Five infants with ACC Type I, presenting with scalp and limb skin defects, were evaluated.
  • Pediatric workup excluded other congenital anomalies or genetic disorders in these cases.

Findings:

  • Conservative wound and skin care resulted in complete defect closure for all patients.
  • A previously undescribed complication of milia formation was observed in one case.
  • While defects healed, skin appendages did not recover, resulting in permanent hairless areas.

Implications:

  • Conservative management is a safe and effective option for many ACC Type I cases.
  • Awareness of potential complications like milia formation is important.
  • Urgent surgical intervention is critical for defects involving major blood vessels to prevent hemorrhage or infection.